Molecular Dynamics Simulation of the Phl p 6 Allergen
نویسندگان
چکیده
Parallel to experimental immunological studies we performed computer simulations of the Phl p 6 allergen from timothy grass (Phleum pratense) pollen employing the Austrian Grid’s [1] infrastructure. The molecular dynamics studies were carried out for up to 40ns simulation time investigating the stability of the allergen. Additionally the reaction of the allergen to drastic sequence modifications was explored and usage of interactive molecular dynamics is proposed.
منابع مشابه
Specific IgE response to different grass pollen allergen components in children undergoing sublingual immunotherapy
UNLABELLED BACKGROUND Grass pollen is a major cause of respiratory allergy worldwide and contain a number of allergens, some of theme (Phl p 1, Phl p 2, Phl p 5, and Phl 6 from Phleum pratense, and their homologous in other grasses) are known as major allergens. The administration of grass pollen extracts by immunotherapy generally induces an initial rise in specific immunoglobulin E (sIgE) ...
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BACKGROUND Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. METHODS Timothy grass pollen was exposed to ozone (O(3)), nitrogen dioxide (NO(2)) and sulphur dioxide (SO(2)) alone or in combination. Allergen content...
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